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Small bumps that are either fluid-filled or look like blisters can be a result of heat rash, especially if you’ve been out in the heat, been sweating, and/or wearing tight clothing. If you have a bright red rash in moist areas where your skin rubs together (think under your arms, behind your knees, or in other skin folds), you may have intertrigo. If a rash suddenly appears after you’ve just started on a new antibiotic, anti-seizure medication or diuretic, you might have a medicine-related rash. This rash starts out as small red splotches that quickly spread to cover large portions of your skin.