Antimicrobial resistance (AMR) occurs when microorganisms such as bacteria, viruses, fungi, and parasites develop resistance to medications that once killed them or inhibited their growth. This phenomenon leads to longer illnesses, higher medical costs, and increased mortality. In Nigeria, AMR has become a pressing public health issue, exacerbated by factors like overuse and misuse of antibiotics, limited access to quality healthcare, and inadequate infection control measures. Addressing AMR requires a multifaceted approach, including strengthening antimicrobial stewardship programs, enhancing public awareness, improving regulatory frameworks, and investing in research and surveillance to monitor resistance patterns and inform policy decisions.